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Collection of CCP hemorrhagic fever viruses' targets ---- CCP出血热病毒靶点合集(内容持续更新)

已更新:2月15日

由Krombacher @Krombacherbeer1(整理人非医学专业人士,请留言指正)

Figure CD38 structure. By Emw - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=8764102


Note: Among the following contents, CD38 is the target announced by Dr. Yan, the most likely targets used by CCP. The other targets are searched by @Krombacher and other Luders and Bewaters. Since @Krombacher is a non-medical specialist, all targets except CD38 have to be verified by medical specialists.

在以下材料中,CD38是闫博士公布的靶点,是CCP最有可能使用的靶点。其他靶点是路德听众(Luders),水力量(Be Waters)搜集。由于@Krombacher是非医学专业人士,除CD38之外的靶点都有待医学专业人士验证。内容持续更新。。。


1. Target name: CD38 靶点名称CD38 (闫丽梦博士公布)


This is the target announced by Dr. Yan, the most likely targets used by CCP.

闫博士公布的靶点,CCP最有可能使用的靶点。


(1) CCP‘s research paper. This paper does not specify which virus causes hemorrhagic fever symptoms. The information of viruses may have been deliberately hidden by the Chinese Communist Party.

中共研究论文, 论文中没有具体说明那种病毒引起出血热症状。病毒的信息可能被中国共产党刻意隐藏。

Down this paper here:

点击下载论文

CD38_Correlation of CD38 expression with the progression of hemorrhagic fever with renal s
.
Download • 2.11MB

(2) Therapeutic targeted medicine -- Daratumumab

治疗性靶向药物 -- 达雷妥尤

Price: around $656.61/100mg

价格:大约每100毫克656.61美元


2. Target name: Sema4D/CD100 靶点名称:Sema4D/CD100 (Krombacher搜集,待验证)


(1) CCP‘s research paper. This paper describes the symptoms of blood fever caused by hantavirus (99 patients in Tangdu hospital).

这篇论文中说明汉坦病毒引起出的血热症状(在唐都医院进行的99名病人测试)。

Down this paper here:

点击下载论文

Sema4D_CD100_Elevated Plasma Soluble Sema4DCD100 Levels Are Associated with Disease Severi
.
Download • 866KB

(2) Therapeutic targeted medicine -- Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag

治疗性靶向药物 -- (中文未知)


Price: around $2517.86/1mg

价格:大约每100微克2600元(人民币)/ 1毫克16000元(人民币)


3. Target name: CD163 靶点名称:CD163 (Krombacher搜集,待验证)


(1) CCP‘s research paper. This paper describes the symptoms of blood fever caused by hantavirus (81 patients in Tangdu hospital).

这篇论文中说明汉坦病毒引起出的血热症状(在唐都医院进行的81名病人测试)。

Down this paper here:

点击下载论文

CD_163_Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patien
.
Download • 1.51MB

(2) Therapeutic targeted medicine -- Human CD163 Protein, His Tag

治疗性靶向药物 -- (中文未知)

Price: around $22000/1mg

价格:大约每100微克3500元(人民币)/ 1毫克22000元(人民币)


4. Target name: Syndecan-1/sCD138 靶点名称:Syndecan-1/sCD138(Krombacher搜集,待验证)


(1) CCP‘s research paper. This paper describes the increase of level of sCD138 caused by hantavirus (176 patients in Tangdu hospital).

这篇论文中说明汉坦病毒引起出的血热症状(在唐都医院进行的176名病人测试)。

Down this paper here:

点击下载论文

syndecan-1_CD138_Study on expression of plasma sCD138 in patients with hemorrhagic fever w
.
Download • 665KB

(2) Therapeutic targeted medicine -- Human Syndecan-1 Protein, His Tag

治疗性靶向药物 -- (中文未知)

Price: around $22000/1mg

价格:大约每100微克3500元(人民币)/ 1毫克22000元(人民币)


5. Target name: PD-1 靶点名称:PD-1(Krombacher搜集,待验证)


(1) Research paper by chinese researchers (You know almost all the researches in China is kind of 'Military-Civil' fusion. It is sure that the Chinese Military also konw this study). This paper describes that PD-1 may serve as a potential therapeutic target in lethal SFTSV infection. This paper is published in Nature Communication

这篇论文中表明PD-1可以作为可能的严重发热伴血小板减少综合征(新型出血热)的治疗靶点。


Down this paper here:

点击下载论文

PD-1_Deficient humoral responses and disrupted B-cell immunity are associated with fatal S
.
Download • 3.39MB

(2) Therapeutic targeted medicine -- Nivolumab (Opdivo) approved by FDA

治疗性靶向药物 -- (纳武单抗)

Price: around $5417/10mL

价格:大约10毫升5417美元


The Chinese Communist Party has already successfully copied this drug.

中共已经成功仿制了这款单抗药物,有多家单位都能生产此款药物。目前2020年降价以后大约价格约7000元(人民币)/100mg。中共有很多公司对PD-1进行量产。其中信达PD-1还列入了医保,价格2800元。



6. Target name: VEGF 靶点名称:VEGF(胡椒面国王@weinixiong0615搜集,待验证)


(1) 细胞骨架重构在 VEGF 与 TNF-α促进汉坦病毒感染致血管内皮细胞通透性增高中的作用及其机制, 第四军医大学博士学位论文

English title: The role and mechanism of cytoskeleton rearrangement and its relationship with VEGF or TNF-α on the hyper-permeability of vascular endothelial cells induced by Hantavirus infection (in Chinese Ph. D dissertation, Air Force Medical University or Fourth Military Medical University)

Down this paper here:

点击下载论文

细胞骨架重构在VEGF与TNF-α促进汉坦病毒感染致血管内皮细胞通透性增高中的作用及其机制
.pdf
Download PDF • 5.75MB

(2) Therapeutic targeted medicine -- Avastin (bevacizumab) approved by FDA

治疗性靶向药物 -- (贝伐珠单抗)



国内有多家药企在研发此药, 已有4家药企通过审批;

There are a number of pharmaceutical companies in China can produce this drug. 4 of them have been approval.







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